Vetter Harold Bien , Emilia Entcheva , Arkady Pertsov , Sergey Mironov and Frederick Cardiac Cell Monolayers Spatial Frequency Content in Optical Mapping
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Spatial frequency content in optical mapping of cardiac cell monolayers.
An elegant study by Mironov et al. used experimental data from paced activation in pig hearts to formulate practical resolution limits in optical mapping of cardiac excitation (4). In the examined conditions, little to no content was found >130Hz in the temporal domain and <3mm in space, thereby justifying the use of aggressive filters to improve signal-to-noise ratio with minimal overall disto...
متن کاملLetters to the Editor Spatial Frequency Content in Optical Mapping of Cardiac Cell Monolayers
Mironov, Sergey F., Frederick J. Vetter, and Arkady M. Pertsov. Fluorescence imaging of cardiac propagation: spectral properties and filtering of optical action potentials. Am J Physiol Heart Circ Physiol 291: H327–H335, 2006.—Fluorescence imaging using voltage-sensitive dyes is an important tool for studying electrical propagation in the heart. Yet, the low amplitude of the voltage-sensitive c...
متن کاملFluorescence imaging of cardiac propagation: spectral properties and filtering of optical action potentials.
Fluorescence imaging using voltage-sensitive dyes is an important tool for studying electrical propagation in the heart. Yet, the low amplitude of the voltage-sensitive component in the fluorescence signal and high acquisition rates dictated by the rapid propagation of the excitation wave front make it difficult to achieve recordings with high signal-to-noise ratios. Although spatially and temp...
متن کاملOptical action potential upstroke morphology reveals near-surface transmural propagation direction.
The analysis of surface-activation patterns and measurements of conduction velocity in ventricular myocardium is complicated by the fact that the electrical wavefront has a complex 3D shape and can approach the heart surface at various angles. Recent theoretical studies suggest that the optical upstroke is sensitive to the subsurface orientation of the wavefront. Our goal here was to (1) establ...
متن کاملLenses and effective spatial resolution in macroscopic optical mapping.
Optical mapping of excitation dynamically tracks electrical waves travelling through cardiac or brain tissue by the use of fluorescent dyes. There are several characteristics that set optical mapping apart from other imaging modalities: dynamically changing signals requiring short exposure times, dim fluorescence demanding sensitive sensors and wide fields of view (low magnification) resulting ...
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تاریخ انتشار 2006